More than 200 researchers and collaborators in the development of gene tools have found substantial evidence related to human genetic variation to disease from real time PCR primer design, helping them to understanding human evolutionary history, grounded in data described in a significant paper recently published.

The result of the international consortium from the United Kingdom, the United States, Canada, Japan, China, and Nigeria, describe common patterns of genetic variation in human DNA on primer design collected from four different sites around the world. Real time PCR (polymerase chain reaction) allows uncovering the root cause of disease and other genetic disorders.

Compared with the evidence of previous scientific work, research suggests that genetic variants located physically closer to each other are inherited as groups. This collective variation are called haplotypes, and the catalog of all of these blocks, usually referred as the "HapMap" today is publicly available to the biomedical research community interested in real time PCR.

In fact, the community has accelerated the development of new gene tools, searching for gene variants in primer design relating to disease, finding new insights into the old scientific conception of the genes involved in human evolution and real time PCR, although inheritance can also influence the different responses to environmental factors or to certain drugs.

David Altshuler, M.D., Ph.D., said "Built upon the foundation laid by the human genome sequence, the HapMap is a powerful new tool for exploring the root causes of common diseases. Such understanding is required for researchers to develop new and much-needed approaches to understand the still-elusive root causes of common diseases such as diabetes, bipolar disorder, cancer and many others".

Although the medical community knows that several causes of disease run in families for generations, it was not until the development of gene tools related to real time PCR, when it was found that half of the risk of diseases is closely related to genetic differences in a primer design, demonstrating that it has been inherited from parents.

Real time PCR is commonly used to determine the underlying causes of common inherited diseases, but the different therapeutic responses are not well known at this time. Studies using primer design are intended to find the necessary information to identify genetic contributors to human health, developing new biomedicine approaches to prevention, diagnosis and treatment.

In the United States, studies to uncover root causes of disease and other real time PCR genetic investigations are lead by the National Human Genome Research Institute (NHGRI) and other centers belonging to the National Institutes of Health (NIH), in association with the International HapMap Consortium.

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